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Advanced Research Projects Agency for Health (ARPA-H)

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Funder (programmatic, ISO-driven) · HHS Research Agency (OTA / ISO-style funding) · Updated 2026-10-19

Newest federal health research agency (est. 2022). Funds breakthrough health technology through Other Transaction Authority (OTA) and ISO-style program structures. Accessible to non-traditional vendors through program-manager-led solicitations.

MMT Read

ARPA-H's procurement model is the access lever. OTA awards are not constrained by FAR-style competition rules, which is why non-traditional vendors and academic-industry teams can win. ADVOCATE moved from solicitation to performers on September 9, 2026 (Atman Health, Tempus AI and UpDoc on the patient-facing agent; Stanford on the supervisory agent; Duke and Kaiser Permanente on implementation), and the agency has launched SPECTRA, SURPASS, BIOGAMI and a biosensors effort since mid-September. The four Mission Office ISOs stay open on a rolling basis; there are no open SBIR/STTR topics right now. The FY2027 request is $945M, $555M below FY2026's $1.5B, and FY2027 opened October 1, 2026 under a continuing resolution to December 11, 2026.

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